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Secondly, IGF-I has been proposed as an index of healthy aging, due to the finding that it directly correlates with the leukocyte telomere length[245, 246], a biomarker of human aging associated with increased risk of developing vascular diseases, metabolic disorders, and other age associated phenotypes[247, 248]

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Numerous pathways, including the GTP cyclohydrolase 1/tetrahydrobiopterin-phospholipid axis (98), the cystine/cysteine-GSH-peroxidase 4 (GPX4) axis (99,100), the ferroptosis suppressor protein 1-coenzyme Q (CoQ) 10 axis on the plasma membrane (101,102) and the mitochondrial dihydroorotate dehydrogenase/CoQ system, serve to counteract ferroptosis and maintain basal lipid peroxidation (103)